Artesunate plus amodiaquine combination therapy: reviewing the evidence
Identifieur interne : 001742 ( Main/Exploration ); précédent : 001741; suivant : 001743Artesunate plus amodiaquine combination therapy: reviewing the evidence
Auteurs : George O. Adjei [Ghana] ; William Kudzi [Ghana] ; Alexander Dodoo [Ghana] ; Jorgen A. L. Kurtzhals [Danemark]Source :
- Drug Development Research [ 0272-4391 ] ; 2010-02.
Abstract
The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ddr.20346
Affiliations:
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Kurtzhals</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Centre for Medical Parasitology at Department of Clinical Microbiology and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Department of International Health, Immunology and Microbiology, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Drug Development Research</title><title level="j" type="sub">New Malaria Drugs</title><title level="j" type="alt">DRUG DEVELOPMENT RESEARCH</title><idno type="ISSN">0272-4391</idno><idno type="eISSN">1098-2299</idno><imprint><biblScope unit="vol">71</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="33">33</biblScope><biblScope unit="page" to="43">43</biblScope><biblScope unit="page-count">11</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02">2010-02</date></imprint><idno type="ISSN">0272-4391</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0272-4391</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed‐dose combination of artemether‐lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first‐line therapy for uncomplicated malaria by National Malaria Control Programs in sub‐Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed. Drug Dev Res 71: 33–43, 2010. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Adjei, George O" sort="Adjei, George O" uniqKey="Adjei G" first="George O." last="Adjei">George O. Adjei</name></region><name sortKey="Adjei, George O" sort="Adjei, George O" uniqKey="Adjei G" first="George O." last="Adjei">George O. Adjei</name><name sortKey="Adjei, George O" sort="Adjei, George O" uniqKey="Adjei G" first="George O." last="Adjei">George O. Adjei</name><name sortKey="Dodoo, Alexander" sort="Dodoo, Alexander" uniqKey="Dodoo A" first="Alexander" last="Dodoo">Alexander Dodoo</name><name sortKey="Kudzi, William" sort="Kudzi, William" uniqKey="Kudzi W" first="William" last="Kudzi">William Kudzi</name></country><country name="Danemark"><noRegion><name sortKey="Kurtzhals, Jorgen A L" sort="Kurtzhals, Jorgen A L" uniqKey="Kurtzhals J" first="Jorgen A. L." last="Kurtzhals">Jorgen A. L. Kurtzhals</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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